Where are all the drugs ai?

A new drug usually begins with a tragedy.

Peter Ray knows that. Born in what zimbabwe, the boy of a mechanical technician, technician, fleece with their family to South Afrafela Zimbabwean war of release of release. If you remember the journey here in 1980 in an armated cars. As the sun burned, a soldier learned at the age of 8 how to fire of the machine. But his mother has run away. She didn’t feel well.

Doctors in Cape Town Diagnosisté cancer. I am Ray reminds of radiation hair with her, hospital rooms, the colostomes pockets. She loved the beach, loved to walk along the line where the water has met the ground. But it has become harder for her. Sometimes I came home from the hospital for a while and looked that things would get better. Ray had his hopes. Then things will fall again. Surgery, radiation, chemotherapy-the treatment that were on the table in the 1980-emerge. When he steady firm, the promise he had to make a difference, somehow. I was 13 years old.

Rays studied to become a Medicalist chemical, first in the SouthPrile Africa, take the pretense to finish their studies, then at Liverpool University. Has worked at drug companies through the UK, on numerous projects. Now 5th century, 53, it is one of the drug designers in a Pharmaceractic company called reign. Think of this promise to his mother very much. “You live with me all life,” he says. “I need to get drugs on the market that cancer.”

The willing to stop your first tragedies from happening to someone else can be a strong motivator. But the process of Discovery drug It’s always grindly, rudely slow. First, chemicals As Ray zero in its intended a protein, a long string of the Africe Africe and folded. They call a pattern of their computer screen and look at a black nest. He would note the curves and decision in his surface, places where a molicle, vacuum through the darkness as a nunia could dok. Then, atom from Atom, they try to build the spacecraft.

When the new molecule is ready, chemicals pass the biologiststhat tries on cells live in warm rooms. More Tragedy: many cells die, for reasons that are not always clear. Biology is complex, and the new drug does not work as planned. Chimbists will have to create each other, and the other, tweaking, ajusting, often for years. A biologist, Keith Mikula of Insilic medicinetold me about their experience in a different drug society. After five years of work, its best molecules had section of income taxis, dangerous ones who have meant they could no longer. “There was a great chemical team, a large team of biologists, thousands of mollecule fact, and no real trouble,” he said.

If a team is very lucky, get a molecule who, in the molecule, doing what I guess. They have a chance to give a small group of healthy human volunteers, a phase i Try. I am If volunteers stay healthy, then then more people, including those who disease in question, in a phase II. If diseases do not be sick, you get a chance of III – to give more to more with more people, many people can, as a most likely food.

To each stage, for the reasons as few people understand and fewer can predict, large drug rafts. More than 90 percent of hope fails along the path. When you met drug hunters, you could ask, justice, tenderminable, if they ever had a drug. “He is ironing arri ,, mikula, having a drug (NRAPARIB, for the ovary cancer) to their name.” We are unicorn. “