“Unmatched” anti -snake made from a person bitten 200 times

Say scientists of the blood of an American man who intentionally introduced himself from the snake poison.

It has been shown that the antibodies in the blood of Tim Fredide protect against the deadly doses from a wide range of species in animal tests.

Modern therapies should correspond to the specific type of poisonous snake that has been bitten.

But Mr. Fredide’s 18 -year mission can be an important step in finding a universal antiver against all snakes – killing up to 14,000 people a year and leave three times more, which require amputations and face constant disabilities.

In general, Mr. Fredide survived more than 200 bites and more than 700 poison, which he prepared from some of the most deadly snakes in the world, including several species of Mamba, cobra, taipan and edges.

Initially, he wanted to create his immunity to protect himself when processing snakes, documenting his feats on YouTube.

But the former truck mechanic said he was “completely twisted” early when two cobra was bitten by continuity, leaving him in a coma.

“I didn’t want to die. I didn’t want to lose my finger. I didn’t want to miss a job,” he said BBC.

Mr. Fredide’s motivation was to develop the best treatments for the rest of the world, explaining: “It just became a way of life, and I just kept pushing and pushing and pushing as much as I could advance – for people who are 8,000 miles away from me dying.”

Currently, antivenom is produced by introducing small doses of a snake in animals, such as horses. Their immune system fights poison by producing antibodies and they are going to use them as therapy.

But the poison and the antine should be compared closely because toxins in the poisonous bite vary from one species to another.

There is even a wide variety in one species – in India Antivenom made of snakes less effectively Against the same species in Sri Lanka.

A team of researchers started looking for a type of immune defense called widely neutralizing antibodies. Instead of focusing on a part of the toxin that makes it unique, they are aimed at details common to whole classes toxin.

It was then that Dr. Jacob Galaville, CEO of Biotech Company Centivax, came across Tim Fred.

“Immediately I looked like” if anyone in the world developed these widely neutralization antibodies, it will be it, “and so I reached out,” he said.

“The first call, I looked like” it might be uncomfortable, but I would like to take my hands from your blood. “

Mr. Fredide agreed, and the work received ethical approval because the study would only take blood, and no more poison.

The study was focused on the elaptids – one of the two families of poisonous snakes – such as coral snakes, mambo, cobra, tape and grate.

Elapids primarily use neurotoxins in their poison, which paralyzes their victim and deadly when stops the muscles needed for breathing.

Researchers have chosen 19 elapidids defined by the World Health Organization as one of the most deadly snakes on the planet. They then began to cleanse Mr. Fredid for protective protection.

Their work, Detailed in Cell’s magazineIdentified two widely neutralized antibodies that can focus on two neurotoxin classes. They added to drugs aimed at the third to make their Antivenom cocktail.

In the experiments on the mice cocktail meant that animals survived deadly doses of 13 of 19 species of poisonous snake. They had partial protection against the other six.

According to Dr. Glansville, it is an “unmatched” width of the defense, which said “probably covers a whole pile of elapsides for which there is no modern anti -spring.”

The team tries to further clarify the antibodies and find out if the fourth component may add to the complete protection against the elapid snake poison.

Another class of snake – viper – more count on hemotoxins that attack blood, not neurotoxins. A total of about a dozen wide classes of a snake’s toxin, which also includes cytotoxins that directly kill cells.

“I think that in the next 10 or 15 years we will have something effective against each of those classes of toxins,” said Professor Peter Kvong, one of the Colombian University researchers.

And hunting continues inside the blood samples of Mr. Fred.

“Tim’s antibodies are really very unusual – he taught his immune system to get it very, very widely recognized,” said Professor Kvong.

Finally Hope – have either one antiwen that can do everything or one injection for the elaptids and one for viper.

Professor Nick Keyvell, who is the head of the Smeibita and intervention center at the Liverpool Tropical Medicine School, said the width of the defense was “was definitely a novel” and gave “strong evidence” that this was a possible approach.

“Undoubtedly, this work moves the field forward in an exciting direction.”

But he warned that “a lot of work should be done”, and that Antivalom still required widespread testing before it could be used in people.

But for Mr. Fred, the achievement of this stage “makes me feel good”.

“I do something good for humanity and it was very important to me. I’m proud of it. It’s pretty cool.”