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Agonists of the GLP-1 receptors (GLP-1 RAS), medicines that help control Diabetes type 2 And obesity can have a deep effect on physical health – what about mental health?
Some examples of these drugs include semoglutides such as Ozempic and Wegovy, as well as lyriclutids such as Victosis and Saxenda.
Different studies have shown on the GLP-1 RAS that causes that causing ras complications of mental healthFor example, anxiety and depression.
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The National Institute of Health (NIH) published research in June 2024, which considered the correlation between semaglutid therapy and “exacerbation of mood violations”.
The study emphasized the association of negative mood changes in patients with type 2 diabetes The story of depressionWarning health care workers to know about this “potential risk”.
Studies discussed the correlation between the GLP-1 RA and the mood change. (Istock)
But more Last studyPublished in the magazine Diabetes, obesity and metabolism, suggested that these mood changes were associated with genetic variations for different populations and ancestors in the UK Biobank.
While the GLP-1 RA variants had “consecutive cardiometabolic effects” in all groups, researchers stated that the negative impact on mental health is “more diverse”, concluding that any change of behavior “is probably not acting directly (medicines).”
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Doctors weigh the medication and mood
Dr. Bret Osborne, Florida neurosurgeon, who often prescribes GLP-1 RAS to his patients, believes that there is no “consistent cause” between these drugs and mental illness.
“Researchers analyzed genetic markers for almost half a million people from different sections of society in search of the connection between the GLP-1 receptors and mental health problems, such as depression, anxiety Either suicide – and they didn’t find it, ”he summarized.
The Agonists of the GLP-1 receptors were associated with mood changes, patients and doctors report. (Istock)
Folk suffering from obesity Or the fight against type 2 diabetes is often depressed without medication, said the doctor.
“These conditions accept the fee – physically, emotionally and socially,” he said. “Yes, yes, most of the patients starting the GLP-1 medicine are already dealing with the fight for mental health. But this is not because of the drug is because of the disease.”
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Once these people begin to lose weight, blood sugar stabilizes and energy improves, which usually also lifts their mood.
“GLP-1 drugs help people restore their health,” Osborne said. “They reduce inflammation. They reduce blood sugar. They Compression of the waist line”
“And when people look and feel better when their bodies finally start working on them, not against them, they often smile more, no less.”
“GLP-1 drugs help people restore their health,” one doctor said. “And when people look and feel better when their bodies finally start working on them, not against them, they often smile more, no less.” (Istock)
Dr. Muhammad Ghana, A Boriatric surgeon At the Institute for Health Loss in Health and Boratrical Surgery, he shared in a separate interview Fox News Digital that while some of his patients report mood changes, others “do not have it at all”.
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“Depression or mood swings are very common regardless of, especially in our time, and therefore it is difficult (determining) whether it is related to the GLP-1 agonists, or it just happens that they started suffering from this after they started this medicine,” he said.
“It is actually difficult to say whether it can change the person that can happen from the slimming, or it is a side effect of the mood change,” he added. “I don’t think we still have enough data to come to this conclusion.”
For those interested in GLP-1 RA medicines, or experience mood changes during their adoption, the expert emphasized the importance of keeping in close contact with medical workers. (Istock)
Patients who lose weight with the GLP-1 RAS may experience the “great stimulus” confidence as well as the change of personality and Even a relationshipAccording to Hunum.
“It really depends on the person and the support system,” he said. “To achieve the conclusion you need the right, randomized controlled trials and best studies to determine whether it is related to the medication itself or just weight loss.”
“This is important for all doctors who prescribe this medicine to find out and check the patient’s history.”
For those interested in these medicines either experience mood swings during their adoption, the surgeon emphasized the importance of keeping in close contact Medical suppliers.
“Just like any other medicines, they can have potential side effects,” he said.
Ghana recommended looking for professionals and practitioners who take a “holistic approach” to slimming, offering in addition to medicines.
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Dr. Brunldo Nazario, MD, editor -in -chief of medical affairs in WebMD, said Fox News Digital that “obesity is difficult”.
“Obesity experts … carefully excited about how well these drugs work,” she said.
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“In modern studies showing contradictory mood disorders and the use of GLP-1 drugs, it is important for all doctors who prescribe this medicine to know and check the patient’s history before prescribing (them).”
“Don’t be afraid to seek help if you feel something wrong – your health depends on it,” one expert suggested. (Istock)
Nazario emphasized that for GLP-1 users it is “vital” listen to their body, urging them to pay attention to their feelings and know the symptoms of mood disorders.
“Don’t be afraid to seek help if you feel something wrong – Your health It depends on it, ”he added.
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Nazario noted that the GLP-1 RAS can affect the mood in different ways.
“They are not all negative – they have the potential to improve the mood,” she said. “Just a vision of great results can increase self -esteem, confidence and body image.”
